The El Capitan Theatre in the Mission District in San Francisco, opened on June 29, 1928. In the 1960's, they hollowed out the building and turned it into a parking garage. I guess you have to desecrate a theater, that's a unique way to do it.
Opened in 1923, the Alexandria Theatre in San Francisco closed in 2004 and is in a shoddy state of repair. There have been talks of restoration, but nothing has yet come to fruition.